Does Semaglutide Expire in 28 Days?

Does semaglutide expire after 28 days once opened?

Yes. Most semaglutide pens (copyright® or Wegovy®) should be used within 28 days after first use. Once opened, the pen is kept at room temperature (up to 86°F / 30°C) or refrigerated, but after 28 days, it should be discarded even if medication remains.

 Why does semaglutide expire in 28 days?

The 28-day limit ensures the medication’s potency and safety. After this period, semaglutide may lose effectiveness, and bacterial contamination risks increase. Manufacturers, including Novo Nordisk, recommend discarding after 28 days to guarantee full strength and safe dosing.

 What happens if you use semaglutide after 28 days?

Using semaglutide past 28 days may result in:

• Reduced effectiveness for blood sugar or weight management

• Inconsistent dosing

• Potential contamination risks
  For best results, always follow storage instructions and discard expired pens.

 Does compounded semaglutide also expire in 28 days?

Yes, but storage may vary. Compounded semaglutide vials often require refrigeration and may have different beyond-use dates (BUD). Many pharmacies also recommend a 28-day window after opening. Always check with your compounding pharmacy for specific instructions.

 How should you store semaglutide to keep it safe?

• Unopened pens → Refrigerate (36°F–46°F / 2°C–8°C)

• Opened pens → Can be kept at room temp (below 86°F / 30°C) or refrigerated

• Do not freeze ❌

• Discard after 28 days from first use, regardless of remaining medication

 Key Takeaway

Semaglutide pens expire 28 days after first use. To stay safe and ensure full effectiveness, follow storage guidelines and replace pens as directed. Compounded versions may vary slightly, so always confirm with your pharmacy.

Medical Disclaimer: This information is for educational purposes only and should not replace medical advice. Always follow your prescriber’s and manufacturer’s instructions.

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